Current Issue : April - June Volume : 2020 Issue Number : 2 Articles : 5 Articles
The present work focuses on the preparation of alginate -based aerogels in the form of \nparticles for their further study as potential drug delivery systems (solid dosage forms). The \ndripping method was used to prepare certain gel particles, and supercritical drying was used to \nobtain final alginate -based aerogel particles. Three model active substances (ketoprofen, \nnimesulide, loratadine) were impregnated into the obtained aerogels using the supercritical \nadsorption process. Using the method of X-ray analysis, it was shown that the in the obtained drug -\nloaded aerogels the corresponding active substances are in an amorphous state, and the stability of \nthis state after six months of storage is confirmed. In vitro dissolution tests for obtained drug -loaded \naerogels was performed. For each sample, an appropriate dissolution medium (with certain pH) \nwas determined. In vitro investigations showed the increasing of the release rate for all model active \nsubstances. Time was required to release and dissolve 50% of the active drug from drug -loaded \naerogels (T1/2), reduced in comparison with pure active drugs in crystalline form. Obtained results \nprovide insight into the application of alginate -based aerogel particles as a drug delivery system to \nimprove pharmacokinetic properties of certain active drugs....
The Cockcroft-Gault (CG) formula is recommended to guide clinicians in the choice\nof the appropriate dosage for direct oral anticoagulants (DOACs). However, the performance\nof the CG formula varies depending on the patientâ??s age, weight, and degree of renal function.\nWe aimed to compare the validity of the CG formula with that of Chronic Kidney Disease\nEpidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) formulae\nfor dosing DOACs. A total of 6268 consecutive patients on anticoagulants for atrial fibrillation\n(AF) were retrospectively investigated. Among underweight and elderly patients, the CG formula\nunderestimated renal function compared with the non-CG formulae. However, the concordant rate of\ndrug indications between the CG and the non-CG formulae was approximately 94%. On-label\nuses under the three formulae were associated with a lower risk of major bleeding (but not\nthromboembolism) compared to warfarin. Although we found differences in estimating renal\nfunction and the proportions of drug indications between the CG and non-CG formulae, the risks\nof thromboembolism and major bleeding were similar to those with warfarin regardless of which\nformula was used....
Embedded three-dimensional printing (e-3DP) is an emerging method for additive\nmanufacturing where semi-solid materials are extruded within a solidifying liquid matrix. Here,\nwe present the first example of employing e-3DP in the pharmaceutical field and demonstrate the\nfabrication of bespoke chewable dosage forms with dual drug loading for potential use in pediatrics.\nLegoTM-like chewable bricks made of edible soft material (gelatin-based matrix) were produced\nby directly extruding novel printing patterns of model drug ink (embedded phase) into a liquid\ngelatin-based matrix (embedding phase) at an elevated temperature (70 DegreeC) to then solidify at room\ntemperature. Dose titration of the two model drugs (paracetamol and ibuprofen) was possible\nby using specially designed printing patterns of the embedded phase to produce varying doses.\nA linearity [R2 = 0.9804 (paracetamol) and 0.9976 (ibuprofen)] was achieved between percentage\nof completion of printing patterns and achieved doses using a multi-step method. The impact of\nembedded phase rheological behavior, the printing speed and the needle size of the embedded\nphase were examined. Owning to their appearance, modular nature, ease of personalizing dose and\ngeometry, and tailoring and potential inclusion of various materials, this new dosage form concept\nholds a substantial promise for novel dosage forms in pediatrics....
Personalised dosing of performance-enhancing food supplements is a hot topic. Beta-alanine is\ncurrently dosed using a fixed dose; however, evidence suggests that this might favour light compared\nto heavy subjects. A weight-relative dose seems to reverse this problem. In the present study, a\nnovel dosing strategy was tested. A fragmented dose, composed of a fixed fragment of 800 mg\nand a weight-relative fragment of 10 mg/kg body weight, was compared to a fixed dose of 1600\nmg and a weight-relative dose of 20 mg/kg body weight in a cohort of 20 subjects with a body\nweight ranging 48 -139 kg ...........................
Daptomycin, a lipopeptide antibiotic, is one of the therapeutic options used for the treatment\nof vancomycin-resistant enterococci (VRE). Recently, the Clinical and Laboratory Standards Institute\n(CLSI) M100 30th edition has removed the susceptibility (S) breakpoint for Enterococcus faecium and\nreplaced it with a susceptible dose-dependent (SDD) breakpoint ........................
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